This volume establishes the conceptual foundation for sustained investigation into tool development in neuroscience. Neuroscience relies on diverse and sophisticated experimental tools, and its ultimate explanatory target-our brains and hence the organ driving our behaviors-catapults the investigation of these research tools into a philosophical spotlight. The chapters in this volume integrate the currently scattered work on tool development in neuroscience into the broader philosophy of science community. They also present an accessible compendium for neuroscientists interested in the broader theoretical dimensions of their experimental practices. The chapters are divided into five thematic sections. Section 1 discusses the development of revolutionary research tools across neuroscience's history and argues to various conclusions concerning the relationship between new research tools and theory progress in neuroscience. Section 2 shows how a focus on research tools and their development in neuroscience transforms some traditional epistemological issues and questions about knowledge production in philosophy of science. Section 3 speaks to the most general questions about the way we characterize the nature of the portion of the world that this science addresses. Section 4 discusses hybrid research tools that integrate laboratory and computational methods in exciting new ways. Finally, Section 5 extends research on tool development to the related science of genetics. The Tools of Neuroscience Experiment will be of interest to philosophers and philosophically minded scientists working at the intersection of philosophy and neuroscience.

Neuroscientists investigate the mechanisms of spatial memory. Molecular biologists study the mechanisms of protein synthesis and the myriad mechanisms of gene regulation. Ecologists study nutrient cycling mechanisms and their devastating imbalances in estuaries such as the Chesapeake Bay. In fact, much of biology and its history involves biologists constructing, evaluating, and revising their understanding of mechanisms. With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species.

What distinguishes good explanations in neuroscience from bad? Carl F. Craver constructs and defends standards for evaluating neuroscientific explanations that are grounded in a systematic view of what neuroscientific explanations are: descriptions of multilevel mechanisms. In developing this approach, he draws on a wide range of examples in the history of neuroscience (e.g. Hodgkin and Huxleys model of the action potential and LTP as a putative explanation for different kinds of memory), as well as recent philosophical work on the nature of scientific explanation. Readers in neuroscience, psychology, the philosophy of mind, and the philosophy of science will find much to provoke and stimulate them in this book.

What distinguishes good explanations in neuroscience from bad? Carl F. Craver constructs and defends standards for evaluating neuroscientific explanations that are grounded in a systematic view of what neuroscientific explanations are: descriptions of multilevel mechanisms. In developing this approach, he draws on a wide range of examples in the history of neuroscience (e.g. Hodgkin and Huxley's model of the action potential and LTP as a putative explanation for different kinds of memory), as well as recent philosophical work on the nature of scientific explanation. Readers in neuroscience, psychology, the philosophy of mind, and the philosophy of science will find much to provoke and stimulate them in this book.

Neuroscientists investigate the mechanisms of spatial memory. Molecular biologists study the mechanisms of protein synthesis and the myriad mechanisms of gene regulation. Ecologists study nutrient cycling mechanisms and their devastating imbalances in estuaries such as the Chesapeake Bay. In fact, much of biology and its history involves biologists constructing, evaluating, and revising their understanding of mechanisms. With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species.